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Research & Developments
 

UGC FUNDED MAJOR RESEARCH PROJECT

TITLE: “Role of molecular markers NF-κβ, IL-1α, IL-6, IL-8, TNF-α, p53 and COX-2 for assessing the malignant potential to oral cancer & their association to therapeutic response in patients with Oral Lichen Planus and Radiation Induced Oral Mucositis”

Chief Advisor: Prof. (Dr.) Mahesh Verma Principal Investigator: Prof. (Dr.) Sunita Gupta

SUMMARY:

The present study was conducted in 60 OLP & 45 RIM patients to evaluate the effective serum level of NF-κβ & associated cytokines (IL-1α, IL-6, IL-8, TNF-α) and also to evaluate the Immunohistochemical expression of P53, COX2 in OLP patients. Following conclusions were drawn:

  1. 80% of the OLP specimens stained positive for nuclear p53 with very mild expression of p53 seen in normal oral mucosa thus confirming the fact that mutant form of p53 is indeed over-expressed in OLP cases.
  2. COX-2 has revealed positive expression in 83.34% of the OLP cases. Significant increase in expression of p53 and COX 2 in OLP can be used as considerable sensitive markers to assess risk for development of malignancy.
  3. The correlation between p53 and COX2 expressions, the present finding showed a non significant correlation, however further studies with larger samples are needed to find out the relation between these two markers.
  4. The serum levels of inflammatory cytokines (TNF-α, NF-κβ, IL-8, IL-6, IL-α) were significantly increased in OLP as well as RIM patients depicting a vital role in pathology & progression of the disease.
  5. There was no significant variation in the levels of cytokines in the patients undergoing radiation as well as chemotherapy and those undergoing just the radiation therapy.
  6. HMGB1 1177G/C polymorphism could be considered as a marker of progression and a marker for poor outcome & recurrence in patients with OLP.
  7. Additionally, HMGB1 haplotypes, rather than individual polymorphisms, could be associated with an increased risk of susceptibility to oral cancer.

The present study provides good evidence to support the hypothesis that p53 and COX2 can be used to identify potential individuals with increased risk of malignant transformation in OLP & as prognostic markers to assess the effectiveness of treatment modalities in management of this disorder. The increased serum levels of inflammatory cytokines in patients with OLP & RIM shows their vital role in the pathophysiology of these disorders and can even be used to assess severity as well as efficacy of various treatment modalities. They can also be breakthrough in the targeted therapy of these disorders. Further studies on the functional relevance of polymorphisms are required to confirm the important role of HMGB1 in cancer and to evaluate HMGB1 as a potential target for the development of novel anticancer therapies.

  • The study of epidemiology, etiology, and providing optimal treatment to the patients of cleft lip and palate in Delhi NCR region

Principal Investigator – Dr. Mahesh Verma
Co Investigator – Dr. Rakesh Sharma
Maulana Azad Institute of Dental sciences, New Delhi started a research project on cleft lip and palate in association with Council for Scientific & Industrial Development Research, New Delhi. The study is a multiphase study with phase-I involving epidemiology of cleft in Delhi and correlating the etiologic factors proposed. Phase II involves treatment and rehabilitation of the patients to be followed by Phase III involving the follow up of the treated patients.
The first district to be selected was the East Delhi region. Directorate of health services was instrumental in selecting and organizing camps at various Government of Delhi dispensaries. During these camps, patients were screened, educated and motivated to undergo treatment at Maulana Azad Institute of Dental Sciences, New Delhi. With the outstanding support and involvement of Department of Community Dentistry, MAIDS, the study project is also going to cover orphanages, children homes and slums. Aanganwadi workers, local NGOs, social and health workers have also been roped in to reach the maximum number of people possible. Till date more than 4000 subjects have been screened and 40 identified patients are undergoing multidisciplinary rehabilitation.  The ultimate goal of the project is to bring smiles on the faces of thousands of affected patients in the Delhi NCR area.

 

  • Evaluation of the Oral Stereognostic Ability of Oral Submucous Fibrosis Patients- An In-Vivo Study.

Principal Investigator: Dr. Mahesh Verma
Co-Investigator: Dr. Komal Maheshwari                   

The present study is being conducted in the Department of Prosthodontics, Maulana Azad Institute of Dental Sciences in association with Council for Scientific & Industrial Development Research, New Delhi. The project aims to evaluate oral stereognostic ability of patients having mild, moderate and advanced OSMF (Study group) and of subjects free from any oral symptoms (Control group) and to relate the findings of this study to clinical implications in the treatment of prosthetic patients. The study comprises of a study group (Group S) and a control (Group C) group. Twelve test pieces made from raw carrot using an acrylic sheet in which the shapes have been cut using a computerized laser machine are being used to determine the Stereognostic Ability in the subjects.
The test pieces are presented in a random order on to the subject’s tongue and they are then instructed to manipulate the introduced piece freely in their oral cavity. No time limit is set for the test and the test is performed three times by each subject in all the four groups.
Oral stereognostic ability is evaluated on the basis of correct recognition responses to the test pieces. More than 30 patients are currently enrolled in the study in various groups.

  • Study of various mechanical properties of dentin post, its comparison with currently available post systems and its clinical implications in human subjects
  • Principal Investigator: Dr. Mahesh Verma
  • Co-Investigators: Dr. Ambica Kathuria Khetarpal

Dr. Sangeeta Talwar

                  Many studies have suggested that post material should have all properties similar to dentin; however, there is an entire lack of in vitro and in vivo studies regarding the usage of dentin itself as post material. The proposed study is being carried out at Department of Conservative Dentistry, Maulana Azad Institute of Dental Sciences in association with Council for Scientific & Industrial Development Research, New Delhi. The aim of this study is to investigate various physical and mechanical properties of dentin posts milled from human root dentin, so that a comparison can be made with other currently available post systems. An understanding of this aspect would provide an invaluable insight in improving the clinical outcome in patients requiring post and core restorations for anterior teeth.

 
Research Projects At MAIDS
  • 1 successfully completed WHO Projects
  • On-going New Millennium Indian Technology Leadership initiative- Dental Implant Project (NMITLI) in collaboration with CSIR
  • 3 On-going CSIR Projects
  • 3 ICMR Projects
  • 1 Dept of Science & Technology Project
  • 24 completed thesis, 16 ongoing thesis
  •  More than 90 publications 2009-11
A. WHO PROJECTS

  • WHO research project titled: Oral health promotion through healthy dietary practices in school children. Dr Mahesh Verma & Dr Harpreet Grewal
B. ICMR PROJECTS

  • “Co-relation between Periodontitis & serum lipid levels: a clinical evaluation” (ICMR). Investigators: Dr. Mahesh Verma, Dr.Arundeep Kaur, Dr. Akshay munjal
  • “Comparison of the effect of laser osteotomy with drill osteotomy on healing following implant placement using resonance frequency analysis : an in vitro study. Dr. Mahesh Verma, Dr Ashish Thomas Kunnekel
  • Task force study for validation of “ICMR criteria for dental fluorosis” Dr. Mahesh Verma, DR Vikrant Mohanty
C. NRHM

  • Project undertaken under “National Rural Health Mission” which includes set-up of two fully equipped mobile dental clinics with two dental chairs each and 2 Information Education and Communication Vehicles.
D. CSIR

  • Research project titled “Designing & manufacture of indigenous dental implants” under the New Millennium Indian technology leadership initiative (NMITLI) funded by Council of Scientific & Industrial research (CSIR). Investigators:   Dr. Mahesh Verma,. Dr Farrukh Faraz., Dr.Abhinav Sood ,Dr Sumit Dubey
  • The study of epidemiology, etiology, and providing optimal treatment to the patients of cleft lip and palate in Delhi NCR region
    Principal Investigator – Dr. Mahesh Verma, Co Investigator – Dr. Rakesh Sharma
  • Evaluation of the Oral Stereognostic Ability of Oral Submucous Fibrosis Patients- An In-Vivo Study. Principal Investigator: Dr. Mahesh Verma, Co-Investigator: Dr. Komal Maheshwari
  • Study of various mechanical properties of dentin post, its comparison with currently available post systems and its clinical implications in human subjects Principal Investigator: Dr. Mahesh Verma, Co-Investigators: Dr. Ambica Kathuria Khetarpal, Dr. Sangeeta Talwar
E. DEPARTMENT OF SCIENCE AND TECHNOLOGY

  • “Fractal anlaysis of extraction socket of bone in extraction socket with and without PRF: a split mouth study Dr. Mahesh Verma, Dr Yuvika
F. THESIS:
COMPLETED THESIS TOPICS:


  1. A comparative study to evaluate the shade matching ability of human eyes under different lighting conditions compared with digital shade guide- Dr Harpreet Kumar Supervisor :Dr.Mahesh Verma
  2. To study the effect of acrylic glazing material on the microhardness & stain  uptake of flexible  & heat processed denture base material- An in vitro study- Dr. Rahul Trikha Supervisor :Dr.Mahesh Verma
  3. Comparison of apical leakage between immediate versus delayed post space preparation at two lengths using Resilon- An invitro study. Dr Kanika Attam Supervisor :Dr.Sangeeta Talwar
  4. Comparison of the efficacy of “f-file” with sonic & ultrasonic debridement to remove artificially placed dentin debris from human root canals-An in vitro study- Dr Gaurav Garg, Supervisor :Dr.Sangeeta Talwar
  5. Shear bond strength of light cure orthodontic bonding agents- a comparative in vitro study  Supervisor :Dr.Tulika Tripathi
  6. “Effect of periodontal therapy on serum C-reactive protein levels – A Clinical Study” Dr. Mandeep Singh    Supervisor : Dr.Arundeep Kaur
  7. “Evaluation of β-tricalcium phosphate in human infrabony periodontal osseous defects – A Clinical Study” Dr. Kirti Chawla :Supervisor Dr.Arundeep Kaur
  8. Comparative evaluation of primary stability,esthetics,and soft tissue response of Zirconia implants with titanium implants-Dr Sudha Rajora,Supervisor: Dr Mahesh Verma
  9. Comparison of the condyle and the articular disk in symptomatic and asymptomatic patients through intracranial view and MRI-Dr Kanu  Aggarwal Supervisor: Dr Mahesh Verma
  10. Evaluation of retention and fracture retention and fracture resistance of different fibre posts-An IN –Vitro study-Dr Varun Pruthi Supervisor:Dr. Sangeeta Talwar
  11. Sterilization of extracted human teeth and effect of various sterilizing agents on fracture resistance of teeth-Dr Amit Abbey Supervisor:Dr. Sangeeta Talwar
  12. Accuracy of bracket placement between Direct and Indirect bonding- A comparative in vitro study-Dr. Arvind S Supervisor :Dr.Tulika Tripathi
  13. Influence of masseter muscle thickness on buccal corridor space and craniofacial morphology- A correlative study-Dr Harneet Kaur Supervisor :Dr.Tulika Tripathi
  14. Evaluation of 2-D and 3-D radiography with direct surgical assessment of periodontalosseous defects- A clinical study-Dr Priyanka Pahwa, Supervisor : Dr.Arundeep Kaur
  15. Periodontal disease and Diabetes Mellitus- A Prevalence study- Dr  Raj  Tiwary, Supervisor : Dr.Arundeep Kaur
  16. Effect of periodontal therapy on Lactoferrin levels in gingival crevicular fluid – Dr. Neha Yadav (2009-2012)
  17. Comparison of Er,Cr:YSGG Laser versus Open flap debridement in periodontal pocket therapy – A Clinical Study – Dr. Manak Gupta (2009-2010)
  18. Comparative evaluation of different calcium phosphorus based agents alone and in combination with fluorides – An invitro study – Dr. Saleem Akhtar (2009-2012)
  19. An invitro cyclic fatigue analysis of different endodontic Ni-Ti Rotary instruments – Dr. Nilav Bhagabati (2009- 2012)
  20. To evaluate the efficacy of three rotary Ni-Ti Retreatment systems in removing gutta percha from Mesio-buccal canal of mandibular first molar – An invitro study – Dr. Nitin Kumar Singh (2009-2012)
  21. Comparison of dimensional accuracy among closed tray, open tray non-splinted, open tray splinted, implant impression technique using polyether, PVS, PVS hybrid material- An invitro study – Dr. Ankur Gupta(2009-2012)
  22. Comparative evaluation of surface conditioning on the retention of CAD- CAM coping, pressible ceramic coping, milled metal coping- An invitro study – Dr. Sapna (2009-2012)
  23. Comparative evaluation of bite opening by Temporary Anchorage devices & Intrusion Arch: An invitro study- Dr. Neha (2009- 2012)
  24. Biochemical & Radiographic skeletal maturity indicators: A comparative Evaluation – Dr. Nimisha (2009-2012)
G. ONGOING THESIS:

  1. Assessment of correlation between Computerized Tomography derived bone parameters and resonance frequency analysed implant stability – a clinical Study – Dr. Vikrant Sainia (2010-2013)
  2. Evaluation of the effect of Er,Cr:YSGG Laser, Ultrasonic unit and curette on root surface profile using surface analyser and scanning electron microscope: An invitro study – Dr. Shipra Arora (2010-2013)
  3. Effect of various chemicals for dissolution of set mineral trioxide aggregate and microhardness of dentin – An invitro study – Dr. Naziya Butt (2010- 2013)
  4. An invitro study to evaluate the safety and efficacy of conventional and newer irrigation methods – Dr. Suman Yadav (2010-2013)
  5. Analysis of C-shaped canal systems in mandibular second molars in Indian Population using surgical microscope and CBCT – Dr. Sanjay Chhabra (2010-2013)
  6. Influence of Design feature of Zirconia coping on fracture resistance of CAD-CAM crown- An invitro study- Dr. Charu Gupta (2010-2013)
  7. Comparison between Er,Cr:YSGG laser, and conventional technique for tooth preparation-- An invitro study – Dr. Pooja Kumari (2010-2013)
  8. Temporomandibular joint remodeling & neuromuscular Adaptation with twin block: MRI & EMG study in adults – Dr. Sandeep (2010-2013)
  9. Evaluation of mini-implant placement: A CBCT study (2010-2013)
  10. Influence of method of conditioning on tensile bond strength of composite bonded to Er,Cr:YSGG laser and bur prepared dentin – an in vitro study Dr Aishvarya kaushik
  11.  CBCT Analysis: A comparative study of dentin removing ability of newer Ni- Ti rotary instruments in curved root canals: Dr. Binu J George 
  12. Comparison of root canal cleaning ability of rotary and reciprocating file techniques: A scanning electron microscopic study: .Dr. Rohit Kansal        
  13. Comparison of computer controlled delivery versus conventional delivery of local anesthesia in periodontal therapies – A clinical study.: Dr. Kamal Aggarwal   
  14. Treatment of infrabony defects with demineralized freeze dried bone allograftalone or in combination with platelet rich fibrin – A clinical study: . Dr. Kamal Sagar 
  15. Comparison of bond strength of ceramic etched with laser, acid and sand blasting. . Dr. Pratap Saini 
  16. Evaluation of changes in pharyngeal airway following twin block therapy. A cephalometric and MRI study. Dr. Ram Gopal